With workplace tools multiplying and personal messages creeping in, it can be hard to get anything done.
I am ruthless about silencing all notifications from almost all applications, and then I tailor the notifications from the remaining apps which I allow to bug me. I am also vigilant to either unsubscribe or make mail rules for any email I don’t want. I auto-silence any call from unknown people, and use RoboKiller to automatically redirect spammers. You can make these things work for you, but it is work. The upshot is that, if there is a red bubble somewhere in my field of view, then I work on it.